Method of producing iron albuminates of organomineral acids.



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To all whom it may concern: v

lie it known that we, PAUL Hosnmo anti Urro Klrrn, subjects of the German Em peror, and, residing, respectively, at'Berlin and tlsnaloriick, Germany, have invented a certain new and useful improved Method of Producing Iron Albuminatesoi Organo mineral Aclcls, of which the following 15}? speclficetlon.

"head, the iron salt forms with the albumen a complex compouncl which is only precipi" total by coagulation when the liquid is heat-- 20 ed. lhe glycero phosphate ot' iron-albuminate thus precipitated which is insoluble in 'Water (lissolves in a. dilute solution of sodium carhonate. containing aquantity of sodium carbonate which is molecularly proportloir ate to the iron. W hen the solution meole 111 this ma'nneris eveporatel an alkali stilt oi glycero-phosphate ot' iron-elhuminete which is easilg; soluble in Water is obtained. The

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alkali salt of the glycero-phosphate of ironnlhuminate which is soluble in Water is also obtained, as may he understood from the above format-ion, when the aqueous albumen solution is first precipitated with ferric chloritl, the iron alhuminate thus obtained being dissolved in an aqueous solution oi" glycerophosphate of alkali, the percentage of alkali of which is equivalent to the quantity of the iron, and evaporated. Also is preferable for the practical execution of the method for obtaining the some compouncl, the albuminote obtained by the action of allrali on the albumen. can be dissolved in alkali, there being added to the solution an aqueous solution of glycero-phosphate of iron containing a quantity of iron which is molecularly proportionate to the alkali and evaporated. in all cases an alkali salt of glycero phosphate of iron alhuniinate is formed. the allralielhuminote is converted. into the alkali salt of glycero-phosphoto of iron-alhuminate, one may also, of course, convert the earth-a]lroli ulhuininote, tor exen le calciuinalhmninate, into the correspon ing' earth-alkali salt oi glycerophosphate ot iron-alhuminute. Like ovulhumen, other alhununnh otlies, as, for exun'r Sneanlcuttonol Letters lle tent. ll Application rioting a, wow. flerielil'o.

rem HGERIN'G, or .ionnmn, are orrro "more, or osunnntloit, tenement.

pie casein, may also be worked up to salts or eartlrallrali salts of glyeero-phosphoto of iron 4 albuminete. il hen glyceropho's phete of iron acts on casein which is insoluble in Water, av glycero -phosphote out is o'otainecl directly which'clissolves in dilute solution of sotlium carbonate; when the solu-- tion is evaporated an alkali salt or glyeerophosphate of iron-ceseinate which is soluble in Water remains behind. it casein is (lie solved in water with an addition of so much alkali that either the acid alkali sell; 1.8% llaOll) or the neutral. allrzili-salt 3.69?) hl'uO'H) is produced, and if such e solution is mixed with the quantity of glj oero-phos, phate of iron which is moleculerly proportionate to the alkali, a clear solution of the alkali-salts of the corresponding glycerophosphate of iron-ceseinate likewise results-. The iron-salt of the glyeero-ohosphete of iron-ceseinale which is insohi Jle utwnler but readily soluble in olilute solution or" sodium carbonate is precipitated by encore o1? iron-salt from these solutions.

lln orcler that'the invent-ion rosy he clearly unclerstoou, the following examples are given by way of enample:-.-

Example 1:100 grins, tlry ovalhunien ore dissolved in 5 liters of water, mixed with e solution of 3G giyc/ero phosphate of iron in 250 grins. or" Water and heated to boiling point. -ihe nrecipitatecl brownish. coagulate is filteretl, weshetii, olried and powdered. J i'tnsteless POWdGP lHSOlHl'JlO in Water and of a hrightliarown color is oi tained which has a pereenta ge of 1.56%

phosphorus and 4.28% iron and "which easily issolves in a dilute solution of curloonato, 109 parts of this preparation ore dissolved in 1200 parts 1 per cent solution of sodium carbonate, alntl if the solution is evaporutecl on glass plates, shining brown KtZ/i leinelhn are obtained which dissolve readily in Water and contain about 9.5 per cent. Water.

Example 2: 3.00 grins. casein are with e solution or. grins. glyeero-phos photo of iron in 506 grins. water for fi l: hours, then filtered and washed with W: The resitine which is insoluble in Water, contains hourn'l iron and glycerophosphorie acicl. Analysis shows a percentage of 2% iron and 1.6% phosphorus. The preparation clissolvcs readily in dilute solution of sodium carhonate, lit 15h) parts of the preperateo.

iron-elhuminete which is insoluble in Water are dissolved in 1120 parts of per cent. solution of sodium carbonate and evaporated to dryness, a powder readily soluble in water remains behind having a bright brown color with about 9. per cent. of moisture.

Example 3: 1,00 grins. casein are dissolved at the ordinary temperature of a room in 1000 grins. of water with an addition of the quantity of sodium hydroxid solution (1.8 grms NaOH) necessary for the formation of an acid salt, whereupon a 10 per cent. solution of the equivalent quantity of glycerophosphate of. iron (4.7 grms.) in water is added. The precipitate which at first appears disappears almost instantaneously and a reddish yellow liquid is obtained which is evaporated to dryness in var-r10 and yields a bright brown residue which is a tasteless, odorless powder readily soluble in water and containing a percentage of 0.757.: of iron.

Example 4: 100 grins. casein are dissolved in 2 liters of water at the ordinary temperature of a. room with an addition of the quan tity of sodium-hydroxid solution (3.0 grins. NaOH) necessary for the formation of the neutral salt, whereupon 9.4' grms. glycero phosphate of iron dissolved in 50 grm water are added to the solution. ,The resulting precipitate is entirely dissolved again. The same quantity of glyccro-phosphate of iron is again added and the iron salt of the glycero-phosphate of iron-caseinatc is obtained as a bright brown precipitate insoluble in water. This precipitate is collected on a filtering cloth, dried and pulverized. The preparation is a bright brown tasteless powder which is not soluble in water and which contains 2.09 per cent. phosphorus and 4.24 per cent. iron; the powder is readily soluble in very dilute solution of sodium carbonate. and therefore also in intestinal fluid.

In the production of the above described preparation, instead of the aqueous solutions, alcoholic suspensions may also be employed with advantage, as is substantiated by a further example.

Example 5: 100 grins. dry neutral sodium caseinate are suspended in 200 grms. alcohol of 90 per cent, whereupon a solution of 9.4 grins. glycero-phosphate of iron in 25 grins. water is added with stirring. \Vhen digested on the water-bath a brownish reaction product is obtained which is filtered arated by means of dilute acids.

with the aid of suction, washed and dried in mono. The brownish powder thus obtained is readily soluble in water and contains 1.5 per cent. of iron. I

The iron is in a complex form in all the above described compounds. Sultureted hydrogen causes no change in the aqueous solution; ammonium sultid produces onlv a green coloration, but boiled with ammonia, the solution remains clear and no hydrate of iron is precipitated. The compounds give in aqueous solution with strong mineral acids a precipitate which contains only a portion of the whole of the phosphoric acid of the undecomposcd product. Iron-albumen compounds are sep- The preparations are easily assimilable. tasteless, iron preparations. which. however. exhibit in addition, according to the nature of the glycero-phosphoric acid which is intimately combined with the albumen, the specific therapeutic action attaching to this latter. which is powerfully supported by the great nutritive value of the preparations.

What we claim as our invention and dcsire to secure by Letters Patent is:-

1. Process for producing alkali salts of glycerdphospluitc of iron-alluuninate, which consists in heating the albumen materials with solutions of glycerdphosphate' of iron, dissolving the insoluble product obtained in dilute alkali-carbonate solution. and evaporating the solution. 1

'2. Asnew products, alkali salts of glycerophosphate of iron-albuminatc. which "are tasteless, soluble in water. yields no precipitate in solution with sulfureted hydrogen, give a green coloration in solution with ammonia sulfid, hydroxid with ammonia. give in aqueous solution with strong mineral acids aprecipitate which contains'o'nly whole of the phosphoric acid of the nudecomposcd product and are'capablc. of'lieing readily assimilated.

' In testimony. whereof. we afiix our signatures in the presence of two \YltHOSSQS.

PJYUT; I'IQERIXG. ()T'IQ KTRLE; Witnesses I Lunw IG Wax unto rriia, FRITZ BAUAL- noprecipitate. Vhen give no precipitate ofirona portion of the 

